Distribution of llq23 Breakpoints Within the M L L Breakpoint Cluster Region in De Novo Acute Leukemia and in Treatment-Related Acute Myeloid Leukemia: Correlation With Scaffold Attachment Regions and Topoisomerase I1 Consensus Binding Sites
نویسنده
چکیده
A major unresolved question for the 11q23 translocations involving MLL is the chromosomal mechanism(s1 leading to these translocations. We have mapped breakpoints within the 8.3-kb BamHl breakpoint cluster region in 31 patients with acute lymphoblastic leukemia and acute myeloid leukemia (AML) de novo and in 8 t-AML patients. In 23 of 31 leukemia de novo patients, MLL breakpoints mapped to the centromeric half (4.57 kb) of the breakpoint cluster region, whereas those in eight de novo patients mapped to the telomeric half (3.87 kb). In contrast, only two t-AML breakpoints mapped in the centromeric half, whereas six mapped in the telomeric half. The difference in distribution of the leukemia de novo breakpoints is statistically significant ( P = .02). A similar difference in distribution of breakpoints between de novo patients and t-AML patients has been reported by others. We identified a lowor weak-affinity scaffold attachment region (SARI mapping just centromeric to the break-
منابع مشابه
Region in De Novo Acute Leukemia and in Treatment-Related Acute Myeloid Leukemia: Correlation With Scaffold Attachment Regions and Topoisomerase I1 Consensus Binding Sites
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The human myeloid-lymphoid leukemia gene, MLL (also called ALL-1, Htrx, or HRX ), maps to chromosomal band 11q23. MLL is involved in translocations that result in de novo acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), mixed lineage leukemia, and also in therapy AML (t-AML) and therapy ALL (t-ALL) resulting from treatment with DNA topoisomerase II (topo II) targeting drugs...
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